As of late June, NB.1.8.1 accounts for approximately 43% of COVID-19 cases in the United States, making it the most common circulating variant.
NB.1.8.1 is a subvariant of LP.8.1, which was dominant earlier in the year. It was first identified in China in January 2025 and has since spread to over 22 countries.
The variant has been informally dubbed “Nimbus” due to its rapid spread and slightly altered genetic makeup